In order to study the cause of ALS outside of the motoneuron and the nervous system in ALS, we have launched a new study on genetic environmental epidemiology. We believe that interactions between genetic predisposition and environmental/behavioral factors and exposures may lead to oxidative stress in patients who develop ALS. In collaboration with Drs. Ottman and Factor Litvak, we have already developed the interview tools for genetic, behavioral and environmental factors. Now, we are conducting a small center-based study in preparation for a future larger population-based study. For genetic factors, we also have been working with Dr. Kottmann, who is investigating motor neuron specific gene expression, and we are also … Continue reading Hiroshi Mitsumoto